Responsive comic layout

For the story telling portion of the 'game' I want to build on Scott McCloud's infinite canvas principles (An exquisite example of which can be found over at Daniel Lieske's Wormworld Saga). I will also be borrowing a principle from modern web development, responsive design. By creating a 'responsive' comic layout, where panels would dynamically resize/reflow, readers would get the best reading conditions for their chosen device.

I'm sure this will introduce all sorts of limitations and complexity but...